Fred Bunz

The paper identifies position-dependent ITR instability in AAV plasmids and develops a stable rAAV vector with full-length native ITRs.

This study shows that adenovirus serotype 5 modulates IRE1α-XBP1 signaling by activating IRE1 but blocking XBP1s production, revealing a novel antiviral mechanism evaded by the virus.

The paper functionally characterizes p53 in telomerase-immortalized human cells and demonstrates the effects of a heterozygous p53 mutation.