Shweta R. Malvankar

This study shows that Complex I inhibition redirects autophagy from bulk turnover to mitochondrial clearance in human cells.

This study identifies initial cleavage sites of γ-secretase substrates NRG1 and CDH1 and confirms the phenylalanine rule at the P2 position.

This study shows that phenylalanine residues in the Notch1 transmembrane domain affect γ-secretase cleavage efficiency and site specificity, similar to the known rule for APP.

This study uses molecular dynamics simulations and mass spectrometry to model how γ-secretase cleaves Notch1, revealing structural dynamics and substrate interactions.