Beat Vögeli

The paper shows imipramine binds to A{beta}(1-42) monomers in vitro using NMR spectroscopy, but not to A{beta}(1-40).

This study shows ZBP1 cannot convert unmodified dsRNA to Z-conformation, unlike ADAR1, revealing a competitive mechanism between these proteins in immune responses.

The paper shows that Zβ domains of ADAR1 and ZBP1 bind to G-quadruplex RNA and DNA with low micromolar affinity, providing experimental evidence for their interaction.

The study shows that Z domain mutations in ADAR1p150 slightly reduce A-to-I editing, likely due to mislocalization rather than editing specificity loss, and suggests phenotypes may stem from ZBP1 inhibition.

This study shows Olduvai domains suppress mitochondrial pathways, delaying cellular maturation and promoting brain size increase in humans.

This study identifies SASH1 as a regulator of melanocyte stem cell maintenance, showing that the S519N variant disrupts its function and links to pigmentation disorders.