Joel S. Griffitts

This paper identifies mechanisms of amino acid toxicity in S. aureus and shows glycine can enhance antibiotic efficacy when combined with D-cycloserine.

This study demonstrates that conjugated symbiosis islands can generate nitrogen-fixing endosymbionts in rhizobia, often as mutualists rather than exploiters, with transmission dynamics influenced by phylogenetic relatedness.

This paper identifies the regulatory DNA elements and amino acid residues in NreA that control Ni tolerance in Mesorhizobium strains from serpentine soils.

The paper investigates the phylogenetic congruence of mobile genetic elements and host chromosomes in wild bacteria, finding that they often co-inherit vertically and that environmental factors influence horizontal transfer.

The paper identifies key interactions in the enzymatic complex responsible for converting cysteine to thiazole in micrococcin biosynthesis, revealing a dynamic mechanism involving transient associations between scaffold and modifying enzymes.

This study engineers efficient transcription termination sequences for T7 RNA polymerase, achieving up to 98% in vivo efficiency and demonstrating cross-polymerase functionality.

The paper investigates how extrachromosomal replicons in Sinorhizobium meliloti influence gene function and metabolism using Tn-seq and metabolic modeling, revealing widespread genetic interactions and functional dependencies.