Christopher M. Hadad

This study investigates CYP1A2's role in metabolizing organophosphorus compounds and finds it selectively degrades thions and is inhibited by OP compounds, suggesting its potential as a bioscavenger.

This study evaluates CYP3A4's metabolism of organophosphorus compounds and finds it preferentially metabolizes thions over oxons, with some compounds inhibiting CYP3A4 activity.

This study investigates how CYP2C9 metabolizes organophosphorus pesticides and nerve agents, finding that it preferentially metabolizes thions over oxons and that binding energy correlates with metabolism and inhibition.

The paper develops pFluor50, a fluorogenic kinetic assay system for high-throughput inhibition screening of six human CYPs, determining KM, Vmax, and inhibition types.