Hartmann Harz

The paper uses super-resolution microscopy to measure enhancer-promoter distances during pluripotency exit, finding minimal changes despite large transcriptional changes.

The paper develops a DNA labeling technique to study chromatin mobility and organization during neural differentiation, finding reduced chromatin mobility and increased compaction in differentiated cells.

The paper shows MNX1 overexpression in t(7;12)(q36;p13) AML is due to enhancer hijacking, not oncofusion, and is common in pediatric cases.

This paper introduces a method to generate densely labeled oligonucleotides for detecting small genomic elements using FISH in single cells.

This study uses a small molecule inhibitor to rapidly and synchronously induce senescence-like features in human cells, enabling analysis of its core regulatory program without paracrine effects.

SPARCS enables genome-wide CRISPR screening for spatial cellular phenotypes by combining laser microdissection with deep learning, identifying key genes involved in autophagosome formation.

The paper quantifies the spatial activity of a Drosophila enhancer through sequence mutagenesis and image analysis, revealing dense regulatory information and novel regulatory logic.

BigStitcher reconstructs high-resolution image datasets from cleared and expanded biological samples, compensating optical distortions for single-cell analysis.