Kate M. MacDonald

This paper introduces a machine learning tool for micronuclei segmentation and refines nuclei-micronuclei relationships using a two-phase labeling approach and a Mask-RCNN model.

The paper shows that dU-rich cytoplasmic DNA inhibits STING-dependent immune responses and enhances anti-PD-L1 therapy efficacy in tumors.

The paper profiles the proteome of micronuclei, cytoplasm, and nuclei in human cells exposed to genotoxins, revealing distinct proteomic features and their implications for DNA damage and chromothripsis.