Author

Michael J. Schnieders

University of IowaORCID 0000-0003-1260-4592Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:Bayesian inference· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Arthur Duston OdelliD· 1 shared Brandon S.J. DaviesiD· 1 shared Brian Hong· 1 shared Chloe Ovel· 1 shared Diana L. KolbeiD· 1 shared Genevieve M. Cox· 1 shared Héla AzaieziD· 1 shared Kaleb C. BierstedtiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperGenetics

Arthur Duston OdellORCID

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2 papers

Recent·Most cited

GeneticsPLoS GeneticsPeer-reviewedSep 30, 2026

The prevalence of protein misfolding as a mechanism for hereditary deafness

Rose A. Gogal, Genevieve M. Cox, Diana L. Kolbe…·Michael J. Schnieders

The paper evaluates computational frameworks to prioritize pathogenic variants in deafness-associated genes, identifying 28,866 VUSs with high pathogenicity probability and improving diagnoses for 12 patients.

DOI 10.1371/journal.pgen.1012085

humanDNA methylation

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BiochemistryScientific ReportsPeer-reviewedFeb 20, 2024

Endothelial Lipase Variant, T111I, Does Not Alter Inhibition by Angiopoietin-like Proteins

Kelli L. Sylvers-Davie, Kaleb C. Bierstedt, Michael J. Schnieders, Brandon S.J. Davies

This study investigates the effect of the T111I variant in endothelial lipase on its activity, structure, and inhibition by ANGPTL3 and ANGPTL4, finding no significant differences from wild-type EL.

2 citations

humanexperimental assay

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