Lars Rogge

Homozygosity for hypomorphic IL23R variants (G149R, G300V, R381Q) partly impairs IL-23-dependent IFN-γ production in patient cells; with L372F (effect inferred), they are enriched in tuberculosis, not MSMD or CMC patients.

The paper identifies and functionally characterizes regulatory variants in DPP9 associated with severe COVID-19 by analyzing genetic risk factors and their impact on gene expression and immune cell function.

This study identifies IL-23's role in shaping the functional plasticity of human MAIT cells, revealing its impact on autoimmunity and cytotoxic functions through AP-1 transcription factors.

The paper develops high-dimensional spectral flow cytometry panels for immune phenotyping in healthy donors and applies them to study immune variation in autoimmune diseases.

This study identifies factors influencing DNA methylation variation in human blood, showing that cytomegalovirus infection and aging drive methylation changes, with cellular composition and DNA sequence as key predictors.

The paper identifies novel genetic and non-genetic factors associated with plasma protein levels in healthy donors, highlighting their impact on immune response variability.