Hugo Guerrero‐Cazares

SiteCELL enables on-site purification and cryopreservation of PBMCs for immune single cell profiling, performing as well as Ficoll density gradient in both lab and rural settings.

This study uses cell-specific proteomics to show that CTSB signaling from glioblastoma cells promotes malignancy by disrupting neurogenesis and inducing senescence in neural progenitor cells near the subventricular zone.

The paper characterizes human microglia transcriptomes and identifies gene expression signatures linked to age, sex, and APOE-ε4, revealing immunometabolic pathway perturbations in neurodegeneration.