Author

Esmeralda Bosman

Utrecht UniversityORCID 0000-0003-1314-4065Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:mouse· 1

Frequent Co-Authors

Enrico MastrobattistaiD· 2 shared Olivier G. de JongiD· 2 shared Annet C. W. van Wesel· 1 shared Antonio Garcia-GuerraiD· 1 shared Charlotte V. HegemaniD· 1 shared Danny WilbieiD· 1 shared Ingmar Y. de Groot· 1 shared Ivana Lansweers· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Enrico MastrobattistaORCID

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2 papers

Recent·Most cited

Molecular BiologyNature CommunicationsPeer-reviewedNov 21, 2025

A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release

Omnia M. Elsharkasy, Charlotte V. Hegeman, Tom A. P. Driedonks…·Olivier G. de Jong

This paper develops a modular strategy for delivering CRISPR-Cas9 via extracellular vesicles using aptamer-based loading and UV-activated cargo release, demonstrating efficient delivery and versatility in Cas9 variants.

32 citationstop 1%

CRISPR screenexperimental assay

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Pharmacology & ToxicologyPLoS ONEPeer-reviewedSep 26, 2025

Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-out

Danny Wilbie, Selma Eising, Vicky Amo-Addae…·Enrico Mastrobattista

This study screens cancer drugs to find those that enhance HDR over NHEJ in CRISPR gene editing, identifying Aurora kinase A inhibitors as promising candidates.

3 citations

mouseCRISPR screen

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