Brodie Lawson

PSoup is an R package that converts knowledge graphs into qualitative, parameter-free models to predict biological network behavior under perturbations.

This paper models Multiple Myeloma treatment with Daratumumab, incorporating drug evasion and off-target effects, and uses optimal control to show increased treatment duration and costs.

This paper introduces a computational method to generate physiologically realistic fibrosis patterns, demonstrating its application to cardiac fibrosis and showing micro-scale variability impacts on electrophysiology.