Author

Jennifer L. Mamrosh

Amgen (United States)ORCID 0000-0003-1391-2706Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Assay:proteomics· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Brett LomenickiD· 2 shared David J. ShermaniD· 2 shared Rati VermaiD· 2 shared Raymond J. DeshaiesiD· 2 shared Alexandra TrkolaiD· 1 shared Allan C. deCampiD· 1 shared Annie MoradianiD· 1 shared Audrey RindleriD· 1 shared

Activity by Year

2021-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

Brett LomenickORCID

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3 papers

Recent·Most cited

ImmunologyCell Host & MicrobePeer-reviewedFeb 1, 2025

Rare twin cysteine residues in the HIV-1 envelope variable region 1 link to neutralization escape and breadth development

Maria C. Hesselman, Marius Zeeb, Peter Rusert…·Alexandra Trkola

The paper identifies rare twin cysteine residues in HIV-1 Env V1 linked to neutralization escape and breadth development.

4 citations

humanproteomics

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Cell BiologyProceedings of the National Academy of SciencesPeer-reviewedApr 24, 2024

The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamics

David J. Sherman, Lei Liu, Jennifer L. Mamrosh…·Raymond J. Deshaies

This study investigates the cellular effects of the PNPLA3-I148M variant, revealing its role in altering lipid droplet-Golgi dynamics and inducing proteomic and transcriptomic changes associated with liver disease.

39 citationstop 2%

humanproteomics

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Molecular BiologybioRxivPreprintOct 7, 2021

A Systematic Interrogation of MHC Class I Peptide Presentation Identifies Constitutive and Compensatory Protein Degradation Pathways

Jennifer L. Mamrosh, David J. Sherman, Joseph R. Cohen…·Raymond J. Deshaies

The paper quantifies MHC Class I peptide origins under UPS perturbation, revealing 30% of peptides are UPS-independent and 10% proteasome-independent, with implications for immune activation.

1 citation

humanproteomics

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