Aaron J. Wilk

CellVoyager autonomously analyzes scRNA-seq data to generate new hypotheses and findings, outperforming existing models and producing scientifically interesting results.

The paper shows that NK cell activation during SARS-CoV-2 infection correlates with reduced neutralization breadth of antibodies.

The paper presents a multimodal epigenome atlas of human immune cells exposed to viral and chemical agents, revealing epigenetic changes in transcription factor binding sites and cytokine networks.

This study identifies NK cell-monocyte interactions as a driver of NK cell activation and dysfunction in severe COVID-19 through computational and in vitro experiments.

This paper identifies activated interstitial macrophages as a key target of SARS-CoV-2 infection in human lung tissue, showing their role in viral takeover, inflammation, and fibrosis.

The paper uses CRISPRa screening and real-world data to identify KCNA6 as a neuronal entry factor for SARS-CoV-2 and shows dalfampridine can suppress viral entry.

Weighted-nearest neighbor (WNN) analysis in Seurat v4 learns per-cell modality weights to define cell states, enabling a 228-antibody human PBMC CITE-seq reference for RNA-only query mapping.