Author

Frida Holm

Karolinska InstitutetORCID 0000-0003-1488-6562Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Qingfei Jiang· 4 shared Sabina Enlund· 4 shared Amanda Ramilo Amor· 3 shared Anna NilssoniD· 3 shared Indranil SinhaiD· 3 shared Ola HermansoniD· 3 shared Shahrzad Shirazi FardiD· 2 shared Cecilia Thomsson· 1 shared

Activity by Year

2024-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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4 shared papersCancer Biology

Qingfei Jiang

Mutual co-authors in cluster

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4 papers

Recent·Most cited

Cancer BiologybioRxivPreprintDec 6, 2025

Widespread remodeling of the RNA editome underlies transcriptional and clinical heterogeneity in pediatric acute lymphoblastic leukemia

Sara Brin Rosenthal, Thomas C. Whisenant, Roman Šášik…·Qingfei Jiang

The paper identifies widespread RNA editing changes in pediatric ALL, linking them to clinical outcomes and potential therapeutic targets.

DOI 10.64898/2025.12.03.692208

humanbulk RNA-seq

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Cancer BiologybioRxivPreprintAug 29, 2025

METTL13 Promotes Pre-Leukemic Transformation and the Development of Pediatric Leukemia

Sabina Enlund, Chae-Eun Lim, Isabella Hoang…·Frida Holm

This study identifies METTL13 as an oncogenic factor promoting pre-leukemic transformation and T-ALL development through its regulation by ADAR1.

DOI 10.1101/2025.08.29.673071

humanexperimental assay

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Cancer BiologyExperimental HematologyPeer-reviewedJan 9, 2025

A Distinct Alternative mRNA Splicing Profile Identifies the Oncogenic CD44 Transcript Variant 3 in KMT2A-Rearranged Pediatric T-cell Acute Lymphoblastic Leukemia Cells

Amanda Ramilo Amor, Sabina Enlund, Indranil Sinha…·Frida Holm

The paper identifies a distinct mRNA splicing profile in KMT2A-rearranged pediatric T-ALL, highlighting CD44v3 as a potential biomarker and therapeutic target.

DOI 10.1016/j.exphem.2025.104712

humanbulk RNA-seq

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Cancer BiologyExperimental Cell ResearchPeer-reviewedMar 30, 2024

The CNS Microenvironment Promotes Leukemia Cell Survival by Disrupting Tumor Suppression and Cell Cycle Regulation in Pediatric T-cell Acute Lymphoblastic Leukemia

Sabina Enlund, Indranil Sinha, Christina Neofytou…·Frida Holm

The paper identifies dysregulated gene expression and epigenetic changes in CNS infiltrated T-ALL that promote survival and relapse, offering potential targets for therapy.

8 citations

humanbulk RNA-seq

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