Guanghui Zhu

This study identifies IGF1R-dependent neutrophil reprogramming in the bone marrow microenvironment during prostate cancer metastasis and shows its therapeutic targeting potential.

TMEformer is a spatial deep learning framework that models tumor microenvironment dependencies and enables virtual perturbation analysis using spatial transcriptomics data.

The paper identifies CD4+CXCR5+PD-1- Tfh cells as prognostic and predictive biomarkers for R-CHOP therapy response in DLBCL using single-cell RNA sequencing and multiplex IHC.

This study shows ZNF397 loss leads to TET2-driven epigenetic changes, lineage plasticity, and resistance to AR-targeted therapies in AR-dependent cancers, with TET2 inhibitors reversing resistance.