Isabel Heidegger

This study identifies the YAP1-TGFβ1 axis as a driver of androgen receptor loss in prostate cancer-associated fibroblasts, showing its role in promoting aggressive disease and resistance to therapy.

The paper optimizes dissociation protocols and uses multimodal profiling to characterize fibromuscular stromal heterogeneity in prostate cancer with clinical relevance.

This study compares two scRNA-seq platforms, finding differences in cell population abundance and mRNA quantification, guiding platform selection and data interpretation.