BiochemistrybioRxivPreprint
UB-MBX-46 is a potent and selective antagonist of the human P2X7 receptor developed by structure-based drug design
Adam C. Oken, Andreea L. Turcu, Eva Tzortzini…·Steven Mansoor
The paper identifies molecular features of the human P2X7 receptor using cryo-EM structures and designs a potent, selective antagonist, UB-MBX-46, with picomolar potency and high selectivity.