Max E. Gottesman

This study uses cryo-EM to reveal structural insights into the translation initiation of leaderless mRNA by examining the uS2-deficient ribosome and its interaction with the lambda cI lmRNA.

The paper develops Indel-Seq to study insertion mechanisms at DNA double-strand breaks, finding insertions arise from transcription and require DNA-PK and ssDNA overhangs.

The paper shows that ARP2/3-dependent nuclear actin polymerization and DNA end-resection coordinate genome reorganization to facilitate homology-directed repair and prevent translocations.

This study uses single-molecule tracking to reveal NusG's functional allocation, interactions, and spatial organization in E. coli, showing its roles in transcription elongation, anti-termination, and coupling with translation.

This study provides structural and functional evidence that NusG links transcription and translation in E. coli by binding both RNA polymerase and the ribosome.