Diego del Alamo

This paper introduces SAbR, a structure-based method for antibody renumbering that outperforms sequence-based methods on de novo-designed molecules and shows high agreement with sequence-based approaches on benchmark structures.

This paper shows that combining ProteinMPNN with AbLang improves antibody design, generating more effective HER2 binders than ProteinMPNN alone.

This paper shows that ESMFold can predict alternate protein conformations and generate interconversion paths between them using sequence embeddings from ESM2.

This paper demonstrates that inverting ESMFold can generate more native-like and expressive protein sequences compared to AFDesign, but with higher memory usage.