Sven Nelander

The paper establishes a multi-omic PDX resource linking GBM invasion phenotypes to molecular programs and therapeutic responses, identifying two invasion modes and a neurodevelopmental factor associated with tumor growth and survival.

This study identifies cell state-specific regulators of glioblastoma invasion routes using single-cell transcriptomics and spatial proteomics, showing their impact on patient survival and therapeutic potential.

This study identifies immunoregulatory dendritic cells in brain tumor draining lymph nodes and shows OX40 can target them to improve immunotherapy.

This paper introduces GlioTrace, an ex vivo imaging and AI framework to track glioblastoma invasion dynamics in patient-derived brain slices, revealing patient-specific invasion patterns and drug responses.

The paper quantifies proliferation and migration rates in glioblastoma cell lines and finds a negative correlation between these rates, supporting the Go or Grow hypothesis.