Akiko Koide

The paper shows WDR5 binds RNA non-specifically, displacing it from the MLL1 complex and inhibiting its catalytic activity.

This study develops antibody-drug conjugates targeting CD97, an aGPCR overexpressed in cancer, showing efficacy against AML and GBM cells with minimal off-target toxicity.

This paper develops a monobody-drug conjugate targeting mutant RAS in multiple myeloma, showing improved anti-tumor effects and safety in vitro and in vivo.

This study identifies CD97 as a targetable vulnerability in glioblastoma through its role in tumor metabolism and signaling, supported by transcriptomic, proteomic, and functional analyses.