Anthony Robert White

This study identifies proteomic and transcriptomic changes in olfactory stem cells from AD and MCI patients, revealing pathway-level overlaps and potential biomarkers.

The paper uses computational drug repurposing to identify N-acetylglucosamine as a potential therapy for CLN3 Batten disease, showing it reduces lipofuscin burden in cell models.

This study examines how wildfire smoke and diesel exhaust affect inflammatory responses in aging human microglia, showing distinct temporal and molecular effects on oxidative stress and cytokine profiles.

This paper develops a patient-derived BBB model to screen copper bis(thiosemicarbazone) complexes for Alzheimer's disease treatment, identifying CuII(dtsm) as a promising candidate with improved BBB permeability and anti-inflammatory effects.

The paper investigates copper availability in sporadic ALS and suggests CuII(atsm) may be therapeutically relevant by improving copper bioavailability.

This study develops a human ALS patient-derived BBB model to show focused ultrasound with microbubbles enhances anti-TDP-43 antibody delivery across the BBB in vitro.

This study shows that microglial ferroptotic stress leads to non-cell autonomous neuronal death in ALS, with a novel inhibitor reducing neurotoxicity.

This study shows that APOE4 increases tau levels in brain endothelial cells, reducing anti-tau antibody delivery across the blood-brain barrier in vitro.

The paper uses olfactory cells from Alzheimer's patients to identify gene expression changes linked to cognitive decline.

This paper develops a method to generate monocyte-derived microglia from ALS patient blood, revealing functional impairments and pathological features associated with disease progression.

This study demonstrates that focused ultrasound with microbubbles enhances the delivery of Aducanumab and anti-Tau antibodies across a human sporadic Alzheimer's disease blood-brain barrier model.

This study shows increased mitochondrial internalization and degradation by astrocytes in Alzheimer's disease, suggesting altered neuron-supporting functions and involvement of S100a4 and Ambra1.

This study develops 3D models of Alzheimer's patient microglia that show distinct disease features and drug responses compared to 2D cultures.

This study identifies disease-specific gene expression and protein secretion patterns in olfactory mucosa cells from Alzheimer's patients, revealing potential diagnostic and mechanistic insights.

This study integrates genetic and gene expression data to identify functional gene networks and drug targets in Alzheimer's disease.