Author

John C. Rose

Stanford MedicineORCID 0000-0003-1810-4337Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1

Frequent Co-Authors

Ellis J. CurtisiD· 2 shared Howard Y. ChangiD· 2 shared Jens LuebeckiD· 2 shared King L. HungiD· 2 shared Matthew G. JonesiD· 2 shared Paul S. MischeliD· 2 shared Vineet BafnaiD· 2 shared Aditi GnanasekariD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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2 shared papersCancer Biology

Ellis J. CurtisORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 15, 2026

scAmp analyzes focal gene amplifications at single-cell resolution

Matthew G. Jones, Natasha E. Weiser, King L. Hung…·Howard Y. Chang

scAmp detects and analyzes ecDNA at single-cell resolution, showing its impact on chromatin accessibility in cancer cells.

2 citations

humanscATAC-seq

𝕏 PostBluesky

Cancer BiologyCancer DiscoveryPeer-reviewedAug 7, 2024

Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair

John C. Rose, Julia A. Belk, Ivy Tsz-Lo Wong…·Howard Y. Chang

This study uses a CRISPR-based method to investigate ecDNA formation, showing efficient circularization and distinct repair pathways for ecDNA and chromosomal scars.

43 citationstop 3%

experimental assaystatistical model

𝕏 PostBluesky

Molecular BiologyNature CommunicationsPeer-reviewedJun 1, 2020

Suppression of unwanted CRISPR/Cas9 editing by co-administration of catalytically inactivating truncated guide RNAs

John C. Rose, Nicholas A. Popp, Chris D. Richardson…·Douglas M. Fowler

This paper introduces dead-RNAs (dRNAs) to suppress unwanted CRISPR/Cas9 off-target and HDR-corrected site cleavage, enabling precise genome editing.

58 citations

CRISPR screenexperimental assay

𝕏 PostBluesky