Vanessa M. Cowton

This study shows that the SARS-CoV-2 Spike H655Y mutation changes protease preference but does not determine cellular tropism, with RBD interactions being more critical for upper airway adaptation.

This study shows SARS-CoV-2 E protein induces LC3 lipidation through the V-ATPase-ATG16L1 axis, which supports viral replication rather than inhibiting it.

This study develops quantitative pipelines using digital pathology and machine learning to assess the virulence of SARS-CoV-2 variants in hamsters, showing that some Omicron sub-lineages have regained virulence.

The paper systematically analyzes proteomic and genomic data of SARS-CoV-2 variants to identify how mutations affect viral gene expression, host interactions, and immune evasion.

The paper examines the impact of IFN-lambda4 on HCV diversity using host and viral genetic data from 485 patients, finding that IFN-lambda4 variants influence viral amino acid diversity and load.