Douwe van Sinderen

This study identifies raffinose as a dietary fiber that promotes bifidobacterial persistence in the gut during weaning, with implications for host health and inflammation.

The paper identifies a novel gene cluster in Bifidobacterium pseudolongum that enables resistant starch utilization, linking CAZyme profiles to niche adaptation in infant and adult microbiomes.

This paper characterizes a PNGaseA enzyme from Bifidobacterium bifidum that preferentially strips N-glycans from peptides over proteins, revealing its structural basis for substrate specificity.

The paper identifies a novel subspecies of Bifidobacterium longum, BL. nexti, in infant gut microbiomes, showing its association with formula feeding and vertical transmission.

The paper creates a mutant fitness compendium for Bifidobacterium breve to identify molecular factors affecting colonization and host-microbe interactions.

This study shows that maternal colonization with Bifidobacterium breve during pregnancy alters fetal brain metabolism and expression of key pathways.

FANGORN provides a quality-checked database of full-length 16S-ITS-23S rRNA operons to improve microbial community classification and phylogenetic analysis.

This study develops an endogenous CRISPR-Cas system for gene editing in Bifidobacterium breve, enabling deletion, substitution, and continuous editing of target genes.