David C. Linehan

This study shows that local delivery of SBRT and IL-12 to PDAC tumors in mice affects bone marrow hematopoiesis, causing both acute and long-term changes.

The paper develops a classifier, DeCAF, to identify permissive and restraining cancer-associated fibroblast subtypes from bulk RNAseq data and validates its clinical relevance across multiple cancer types.

This study investigates the role of immunosuppressive neutrophils in SBRT-treated murine PDAC and shows that re-wiring them with IL-12 improves treatment efficacy.

This paper demonstrates a combination treatment of SBRT and IL-12 mRNA in murine pancreatic tumors, achieving cures in both primary and metastatic models by enhancing T cell responses.