BiochemistryMolecular CellPeer-reviewed
Alpha-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation
Cole S. Sitron, Victoria A. Trinkaus, Ana Galesic…·F. Ulrich Hartl
This study shows that alpha-synuclein fibrils sequester and degrade ESCRT-III proteins, leading to endolysosomal damage and increased alpha-synuclein aggregation.
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