Author

Anja Krippner‐Heidenreich

Princess Máxima CenterORCID 0000-0003-1927-9286Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:flow cytometry· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Olaf T HeidenreichiD· 3 shared Minoo AshtianiiD· 2 shared Anita T. van Oort· 1 shared Annelisa M. CorneliD· 1 shared Bert A. van der ReijdeniD· 1 shared Branco M. H. HeutsiD· 1 shared Christian Michel ZwaaniD· 1 shared Constanze BoniferiD· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

Olaf T HeidenreichORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintFeb 13, 2025

RUNX1::RUNX1T1 Depletion Eliminates Stemness and Induces Bidirectional Differentiation of Acute Myeloid Leukemia

Polina K. Derevyanko, Laura E. Swart, L. Daniel Mata Casimiro…·Olaf T Heidenreich

This study shows that depletion of RUNX1::RUNX1T1 in AML cells reduces stemness and promotes differentiation into granulocytic and eosinophilic/mast cell-like populations.

DOI 10.1101/2025.02.13.637937

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologyLeukemiaPeer-reviewedDec 4, 2024

The neuronal homeobox transcription factor HMX3 is a crucial vulnerability factor in MECOM-negative KMT2A::MLLT3 acute myelomonocytic leukemia

Saioa Arza-Apalategi, Branco M. H. Heuts, Saskia M. Bergevoet…·Bert A. van der Reijden

The paper identifies HMX3 as a critical vulnerability in MECOM-negative KMT2A::MLLT3 AML, showing it promotes proliferation and blocks differentiation.

4 citations

humanbulk RNA-seq

𝕏 PostBluesky

ImmunologyHaematologicaPeer-reviewedAug 8, 2024

Repurposing CD19-directed immunotherapies for pediatric t(8;21) acute myeloid leukemia

Farnaz Barneh, Joost B. Koedijk, Noa Esther Wijnen…·Olaf T Heidenreich

This study evaluates CD19 expression in pediatric AML and shows that CD19-directed immunotherapies are effective against CD19+ AML, similar to their efficacy in BCP-ALL.

4 citations

humanflow cytometry

𝕏 PostBluesky