Thomas E. Cleveland

This study generates glycoengineered recombinant alpha1-antitrypsin with in vitro and in vivo activities comparable to plasma-derived A1AT, offering a sustainable therapeutic alternative.

This study isolates and characterizes a diverse panel of marburgvirus glycoprotein-specific monoclonal antibodies from a Rhesus macaque immunized with multivalent filovirus antigens, revealing novel epitopes and potential therapeutic candidates.

This study uses molecular dynamics simulations to show that CFTR misfolds due to entropic penalties, even in wild-type forms, and suggests this contributes to disease in mutants like F508del.