Author

Thomas A. Angelovich

RMIT UniversityORCID 0000-0003-2069-0451Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexander A. KhromykhiD· 3 shared Anthony Dominic KelleheriD· 3 shared Anupriya AggarwaliD· 3 shared Camille EsneauiD· 3 shared Cesar L. MorenoiD· 3 shared Christina FichteriD· 3 shared Fabienne BrilotiD· 3 shared G. Gregory NeelyiD· 3 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

Alexander A. KhromykhORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintSep 24, 2026

Proteolytic control of the SARS-CoV-2 furin cleavage site defines the phenotypic evolution from the pandemic to endemic state

Anupriya Aggarwal, Samantha Ognenovska, Timothy Ison…·Stuart Grant Turville

The paper shows how SARS-CoV-2 variants, particularly Omicron, evolved proteolytic controls at the Spike furin cleavage site to enhance transmission while reducing lower respiratory tract pathogenicity.

DOI 10.64898/2026.09.23.753140

humanproteomics

𝕏 PostBluesky

MicrobiologybioRxivPreprintJul 7, 2025

Replication of SARS-CoV-2 Omicron lineages is defined by TMPRSS2 use in environments where ACE2 is complexed with solute carriers SLC6A19 and SLC6A20.

Anupriya Aggarwal, Samantha Ognenovska, Timothy Ison…·Stuart Grant Turville

This paper shows that SARS-CoV-2 Omicron lineages replicate using a specific ACE2 pool that does not complex with TMPRSS2, unlike pre-Omicron variants.

3 citations

humanspatial transcriptomics

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MicrobiologybioRxivPreprintSep 22, 2023

TMPRSS2 activation of Omicron lineage Spike glycoprotein is regulated by Collectrin-like domain of ACE2

Anupriya Aggarwal, Christina Fichter, Vanessa Milogiannakis…·Stuart Grant Turville

The paper shows Omicron SARS-CoV-2 lineages rely on ACE2 without TMPRSS2 complexes for entry, due to changes in the ACE2 Collectrin-Like Domain affecting TMPRSS2 activation.

6 citations

humanproteomics

𝕏 PostBluesky