Maria Wahle

The paper demonstrates a method to simultaneously measure genome and proteome from the same cells in archival FFPE tissue, applied to melanoma.

The paper constructs a cell type-resolved proteomic atlas of the human body using Deep Visual Proteomics, revealing protein abundance patterns and uncovering cancer-testis antigens in oocytes.

This study investigates how kinase inhibitors reshape the immunopeptidome in CML by altering HLA-I peptide presentation through three molecular mechanisms.

The paper introduces a novel hybrid mass spectrometer, Stellar MS, enabling rapid and sensitive clinical biomarker validation using 15N labeled proteins.

This study uses spatial proteomics and machine learning to analyze AATD in human liver tissue, revealing peroxisomal upregulation and a terminal hepatocyte state with distinct proteomic signatures.

The paper introduces scDVP, a spatial single-cell proteomics method, and finds that half of the murine hepatocyte proteome varies spatially within liver tissue.

The paper develops a sensitive method to analyze HLA peptides in plasma, revealing stable and tissue-representative immunopeptidomes with potential for biomarker discovery.

This paper introduces a multiplex-DIA workflow that enhances single-cell proteome depth using dimethyl labeling and a reference channel, achieving reliable quantification of nearly 4,000 proteins per cell.

AlphaPeptDeep predicts peptide properties using deep learning, offering a modular framework that matches or exceeds existing tools for retention time, ion mobility, and fragment intensity prediction.