Ivan Molineris

The paper shows that brain injury reactivates a developmental program in astrocytes to generate transient LGE-class interneurons that integrate into neural circuits.

The paper identifies Ohno-miRNAs, intragenic miRNA pairs from whole-genome duplication, and shows they have higher retention rates, sequence similarity, and regulate common targets compared to SSD miRNAs.

The paper trains an ensemble classifier to predict cetuximab sensitivity in colorectal cancer PDXs using multi-omic data, achieving high accuracy and demonstrating its utility for therapeutic biomarker development.

This study shows FVIII regulates endothelial cell functionality and vessel stability, with therapeutic potential in haemophilia A.

This study shows Nr2f1 regulates mitochondrial dynamics in adult-born hippocampal neurons, linking it to BBSOAS pathogenesis.

The paper curates a database of RNA-DNA binding sites and introduces a tool to predict RNA:DNA:DNA triple helices, showing most lncRNAs can bind the genome via this mechanism.

The paper uses somatic mutation patterns from cancer to predict genes involved in phenotypic abnormalities and genetic diseases, showing their predictive power is independent of germline-based methods.