Sofya K. Garushyants

The paper identifies YprA family helicases as a missing link connecting DISARM and Druantia immune systems in prokaryotes, revealing new defense classes and their antiviral mechanisms.

This study investigates how Druantia III and Zorya II antiphage defence systems in bacteria synergize through shared DNA intermediates, showing their coordinated response during phage infection.

This study identifies Tmn as a bacterial membrane protein that blocks phage spread by inducing plasmolysis and activates synergistic defence responses through ATP depletion.

The paper introduces KlebPhaCol, a resource containing 53 phages and 74 Klebsiella isolates, including a novel gut phage order, to advance understanding of Klebsiella-phage interactions.

This study develops a mathematical model to show that prokaryotes evolve antivirus defense strategies based on environmental virus prevalence, with adaptive immunity optimal in stable environments and HGT dominant in fluctuating ones.

The paper investigates how mtDNA deletion variants (rho-) outcompete wild-type mtDNA (rho+) in yeast, finding higher copy numbers and intracellular fitness advantage contribute to biased inheritance.

This study quantifies the contribution of gene gain and loss versus genome rearrangements to gene order evolution in bacteria and archaea, finding gene gain and loss dominate.

This study shows that environmental variation and horizontal gene transfer can stabilize microbial diversity and ecological complexity in a mathematical model of competing populations.

The paper identifies non-essential ribosomal proteins in bacteria and archaea by analyzing gene absences in the COG database and linking them to ribosome structure and genome evolution.

The paper presents methods to improve fetal variant calling accuracy in the presence of maternal cell contamination using Bayesian models and learned genotype-correction models.