Author

Yih-Chih Chan

The University of MelbourneORCID 0000-0003-2177-5406Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Mark A. DawsoniD· 3 shared Enid Y.N. LamiD· 2 shared Kathy KnezeviciD· 2 shared Aishwarya KulkarniiD· 1 shared Andrea GillespieiD· 1 shared Anelya MuratiD· 1 shared Benjamin J. BlythiD· 1 shared Benjamin L. ParkeriD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCancer Biology

Mark A. DawsonORCID

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3 papers

Recent·Most cited

Cancer BiologyCancer DiscoveryPeer-reviewedJun 19, 2025

Catalytic inhibition of KAT6/KAT7 enhances the efficacy and overcomes primary and acquired resistance to Menin inhibitors in MLL leukaemia

Shellaina J.V. Gordon, Florian Perner, Laura MacPherson…·Mark A. Dawson

The paper shows that inhibiting KAT6/KAT7 enhances Menin inhibitor efficacy and overcomes resistance in MLL-FP leukemia.

31 citationstop 1%

humanexperimental assay

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Cancer BiologyEMBO ReportsPeer-reviewedAug 5, 2024

Identification of resistance mechanisms to small-molecule inhibition of TEAD-regulated transcription

Aishwarya Kulkarni, Varshini Mohan, Tracy Tzu-Ling Tang…·Kieran F. Harvey

This study identifies resistance mechanisms to TEAD inhibitors by showing MAPK hyperactivation can counteract their effects and suggests combining TEAD and MEK inhibition as a therapeutic strategy.

18 citations

humanbulk RNA-seq

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Molecular BiologybioRxivPreprintMar 17, 2023

CRISPR-ChIP delineates a Menin-dependent oncogenic DOT1L complex in MLL-leukaemia

Omer Gilan, Charles C. Bell, Laure Talarmain…·Mark A. Dawson

The paper introduces CRISPR-ChIP to identify chromatin factors associated with histone modifications in MLL-leukaemia, revealing distinct DOT1L complexes with oncogenic and endogenous functions.

DOI 10.1101/2023.03.17.533231

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