Kieran F. Harvey

The paper shows Hippo pathway disruption in Drosophila eye development leads to loss of cone and primary pigment cell fates due to increased EGFR pathway repressor activity.

This paper introduces Airy beam light sheet microscopy to image subcellular dynamics in large tissues with high spatial and temporal resolution across multiple organisms and biological processes.

This study shows Zyxin and Ajuba limit Hippo signaling and promote Drosophila tissue growth by regulating junctions and Warts kinase activity.

This study uses live microscopy to show that Hippo signalling regulates transcription by controlling the DNA dwell times of YAP and TEAD proteins.

Damsel provides an R package for end-to-end analysis of DamID sequencing data, including quantification, testing, and visualization of protein-DNA interactions.

This study identifies resistance mechanisms to TEAD inhibitors by showing MAPK hyperactivation can counteract their effects and suggests combining TEAD and MEK inhibition as a therapeutic strategy.

The paper identifies how JNK and Hippo pathways regulate epithelial integrity by controlling an overlapping transcriptome, preventing tumour initiation through shared gene repression.

The paper identifies basal spot junctions in Drosophila epithelial tissues that respond to mechanical forces and regulate Hippo signaling by sequestering Warts kinase.

This study shows that dedifferentiation-derived neural stem cells (NSCs) fail to express late temporal transcription factors, leading to impaired neuronal diversity and cell cycle progression.

This study identifies Crumbs and the apical spectrin cytoskeleton as regulators of R8 cell fate in Drosophila eye, distinct from their role in Hippo-dependent organ growth.

The paper identifies a PP2A-Integrator complex that opposes CDK9 activity to regulate transcription and shows its therapeutic synergy in leukemia.

This study identifies Pits and CtBP as Tgi-interacting proteins that cooperate in transcriptional repression of Hippo pathway target genes in Drosophila, with conservation in human orthologs.