Sieghart Sopper

The paper integrates single-cell data from CRC patients to identify immune subtypes and neutrophil phenotypes, revealing their spatial organization and tumor-induced changes.

The paper optimizes dissociation protocols and uses multimodal profiling to characterize fibromuscular stromal heterogeneity in prostate cancer with clinical relevance.

This study compares two scRNA-seq platforms, finding differences in cell population abundance and mRNA quantification, guiding platform selection and data interpretation.

quanTIseq estimates absolute fractions of ten immune cell types from bulk RNA-seq; across TCGA, CXCL9/CXCR3 expression, not mutational load, tracks CD8+ T cell infiltration.