Viet Loan Dao Thi

This paper introduces a chromosomally integrated yeast surface display system for scalable, quantitative antibody profiling and serological assays.

This study identifies ZDHHC17-mediated palmitoylation of HEV ORF3 protein as critical for directional secretion in polarized epithelial cells.

This study identifies bemnifosbuvir as a potent inhibitor of hepatitis E virus replication in vitro and in a gerbil model, with additive effects when combined with ribavirin.

This study identifies integrin beta 1 as a cofactor for naked hepatitis E virus entry, revealing distinct endocytic pathways for naked and enveloped HEV particles.

This study identifies RBM39 as a regulator of innate immunity by controlling transcription and splicing of key interferon response factors, revealing its potential as a therapeutic target.

This study shows that Hepatitis E Virus (HEV) ORF2 protein modulates plasmacytoid dendritic cell (pDC)-mediated antiviral responses by affecting pDC recognition of infected cells.

This study identifies ORF2 as a key HEV protein that suppresses antiviral responses in hepatocytes, enabling viral persistence.

This study shows that hepatocyte-like cells derived from human pluripotent stem cells are permissive to hepatitis D virus infection and can be used to study HDV biology and test therapies.

This study identifies lysosomal cathepsins, particularly CTSL, as critical for HEV entry and demonstrates the antiviral efficacy of the pan-cathepsin inhibitor K11777.

The paper longitudinally characterizes HEV-specific CD4 T cells and neutralizing antibodies targeting nHEV and eHEV in acute and resolved HEV infection, finding capsid-specific immunity dominates and correlates with nAb responses.