Author

Kevin Fedkenheuer

National Institutes of HealthORCID 0000-0003-2327-420XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Organism:human· 3 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Assay:DNA methylation· 1 Approach:machine learning (classical)· 1 Research Focus:trajectory inference· 1

Frequent Co-Authors

Laura L. ElnitskiiD· 3 shared David O. HollandiD· 2 shared Hua TaniD· 2 shared Sara R. Bang-ChristenseniD· 2 shared Sushil Kumar JaiswaliD· 2 shared Valer GoteaiD· 2 shared Abdel G. ElkahlouniD· 1 shared Adam G. SowalskyiD· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCancer Biology

Laura L. ElnitskiORCID

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3 papers

Recent·Most cited

Cancer BiologybioRxivPreprintSep 16, 2025

Discovery and performance of DNA methylation panels for cancer detection and classification in blood

Gennady Margolin, Sara R. Bang-Christensen, Sara A. Grimm…·Laura L. Elnitski

This paper identifies DNA methylation biomarker panels for multi-cancer detection and tissue-of-origin classification using blood samples, achieving high sensitivity and low false positive rates.

DOI 10.1101/2025.09.16.676542

humanDNA methylation

𝕏 PostBluesky

Cancer BiologyPLoS Computational BiologyPeer-reviewedMar 7, 2025

SoMAS: Finding somatic mutations associated with alternative splicing in human cancers

Hua Tan, Valer Gotea, Sushil Kumar Jaiswal…·Laura L. Elnitski

SoMAS identifies somatic mutations linked to alternative splicing in 33 cancer types, revealing 908 genes associated with altered isoform expression across multiple cancers.

DOI 10.1371/journal.pcbi.1012847

humanwhole-exome sequencing

𝕏 PostBluesky

GenomicsPLoS Computational BiologyPeer-reviewedMay 13, 2022

Characterization and clustering of kinase isoform expression in metastatic melanoma

David O. Holland, Valer Gotea, Kevin Fedkenheuer…·Laura L. Elnitski

The paper quantifies gene and isoform expression changes in metastatic melanoma compared to primary tumors, identifies distinct expression patterns linked to mutational subtypes, and highlights potential therapeutic targets.

7 citations

humanbulk RNA-seq

𝕏 PostBluesky