Author

Roger Frigerio Castilho

Universidade Estadual de Campinas (UNICAMP)ORCID 0000-0003-2338-8717Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

Carlos H. SpontoniD· 2 shared Fernando Valdivieso RiveraiD· 2 shared Marcelo Alves Silva MoriiD· 2 shared Pedro M. Moraes‐VieiraiD· 2 shared Vanessa de Oliveira FurinoiD· 2 shared Adriana Leandra SantoroiD· 1 shared Alexander BarteltiD· 1 shared Anna S JungiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersPhysiology

Carlos H. SpontonORCID

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2 papers

Recent·Most cited

PhysiologyEMBO ReportsPeer-reviewedJun 22, 2026

E4BP4 Safeguards Brown Fat Mitochondria from Obesity-Induced Fragmentation via Ceramide Repression

Fernando Valdivieso Rivera, Vanessa de Oliveira Furino, Carlos Eduardo Pinheiro Leher…·Carlos H. Sponton

This study identifies E4BP4 as a transcriptional repressor that prevents obesity-induced mitochondrial fragmentation in brown fat by inhibiting ceramide synthesis, improving glucose homeostasis without weight loss.

DOI 10.1038/s44319-026-00826-0

mousebulk RNA-seq

𝕏 PostBluesky

Cell BiologyThe EMBO JournalPeer-reviewedSep 16, 2024

IF1 is a cold-regulated switch of ATP synthase to support thermogenesis in brown fat

Henver S. Brunetta, Anna S Jung, Fernando Valdivieso Rivera…·Alexander Bartelt

This paper identifies IF1 as a cold-regulated inhibitor of ATP synthase that facilitates reverse mode activity in brown fat to support thermogenesis.

16 citations

mouseproteomics

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