Ianthe A. E. M. van Belzen

This study shows that a single chromosome 3p break initiates ccRCC evolution by creating a fitness bottleneck that selects for recurrent aneuploidies.

This study shows that a genetically engineered mouse model of osteosarcoma recapitulates the genomic complexity and driver mutations observed in human osteosarcoma.

This study identifies chromothripsis and a novel LTA chromothripsis mechanism driving genome complexity and evolution in osteosarcoma, with prognostic implications for high-grade tumors.

The paper identifies prevalent and pathogenic complex structural variations in pediatric solid tumors, linking them to adverse clinical outcomes and potential therapeutic targets.

This paper develops a method to detect tumor-specific gene fusions in pediatric cancer by integrating RNA-seq and WGS, identifying 165 high-confidence fusions and their structural variants.

PhyRepID quantifies protein repeat evolution across 14 vertebrate species by detecting repeats, optimizing detection, and using phylogenetics to derive a PRD score for large-scale comparison.