Weikun Wu

Pallatom2 is a generative model for protein design that achieves high-affinity binder discovery and experimental success across multiple targets.

Pallatom generates protein structures with all-atom coordinates, improving designability, diversity, and novelty in protein design.

The paper predicts single point mutations in SARS-CoV-2 RBD that enhance binding affinity to hACE2 using in silico methods and validates them with SPR assays.