Yoshinori Ohsumi

This study identifies structural and mechanistic principles of Atg15 activation and membrane recognition using MD simulations and experimental validation.

The paper shows that Pho85, a non-canonical CDK, initiates a pathway to restart the cell cycle after stress by phosphorylating Sch9 and Whi5, enabling cell survival.

This study identifies Atg15 as the sole vacuolar phospholipase required for autophagic body membrane disruption, showing its activation by Pep4 and Prb1 and broad substrate specificity.

This study isolates and characterizes autophagic bodies from yeast to identify autophagy cargos and examine cargo selectivity.