Frederik Van den Broeck

This study investigates the co-phylogenetic history of Leishmania parasites and Leishmaniavirus, finding strong phylogenetic congruence at the subgenus and species level, with weaker signals in some cases due to intraspecific host switching.

The paper analyzes the genomic diversity of Leishmania (Viannia) braziliensis across the Neotropical Realm, identifying two major parasite groups associated with different biomes and highlighting ecological and epidemiological differences.

The paper demonstrates drug tolerance in Leishmania braziliensis strains through in vitro models, showing quiescence and reversibility without genetic resistance.

This study analyzes the genome diversity of Leishmania aethiopica, identifying interspecific hybrids and revealing genetic diversity and recombination patterns.

This study investigates how aneuploidy and polyclonality contribute to Leishmania's adaptation to high drug pressure, showing different dynamics depending on the drug and pre-existing mutations.

The paper uses high throughput single-cell genome sequencing to study mosaic aneuploidy in Leishmania donovani, finding rapid karyotype changes and chromosome-specific adaptations.

This paper uses a Darwinian model to show that mass drug administration alone is unlikely to eliminate schistosomiasis due to persistent parasite genetic diversity in untreated hosts.

This study examines the evolutionary history and hybridization of Leishmania parasites using whole genome sequencing, revealing ecological divergence and genetic mosaic ancestry in hybrids.

This paper uses high-throughput single-cell genome sequencing to analyze karyotype variation in a clonal Leishmania donovani population, revealing mosaic aneuploidy and its potential adaptive role.

This study shows T. cruzi maintains sexual populations alongside clonal parasexual ones, with distinct genomic structures and reproductive modes.