Cancer BiologyCancer ResearchPeer-reviewed
Osteoclast-Cancer Cell Metabolic Symbiosis Renders PARP Inhibitor Therapy Resistance in Bone Metastasis
Huijuan Fan, Zhanao Xu, Ke Yao…·Hanqiu Zheng
This study identifies a metabolic symbiosis between osteoclasts and cancer cells in bone metastasis that contributes to PARP inhibitor resistance, showing that targeting this interaction with PARPi and zoledronate can synergistically reduce metastasis.
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