Shi Huang

This study analyzes 43 fully sequenced human Y chromosomes to evaluate the Recent Out of Africa and Recent Out of East Asia models of modern human origins, finding stronger support for the latter.

The paper analyzes genetic data to verify historical claims about the origin of the Huang surname and related lineages, finding haplotype patterns that align with historical records.

ERVcancer provides a database to query activation of human endogenous retroviruses across cancer types using RNA-seq data from multiple sources.

The paper analyzes genetic diversity patterns across human ethnic groups using the 1000 Genomes Project data, identifying group-specific fixed alleles and their evolutionary implications.

The paper analyzes ancient DNA from 12 Neolithic Chinese samples to explore relationships between Y haplotypes and archaeological records, finding close links between certain haplotypes and specific cultural groups.

The paper reanalyzes public DNA data to assess the Paleoamerican and Solutrean models for the peopling of the Americas, finding genetic links between ancient and modern populations.

The paper links Neolithic Y haplotypes to autism spectrum disorder (ASD) by showing higher frequencies of low SES haplotypes in ASD fathers and a male-biased ASD ratio in related surnames.

The paper identifies a set of SNPs with higher minor allele content in lung cancer cases, leading to a predictive risk score that identifies 2.6% of cases with 100% specificity.

The paper examines genetic relationships in ASD trios, finding smaller genetic distance in spousal pairs with ASD-affected children and higher minor allele content in cases for ASD-associated SNPs.