Lihong Zhang

This paper identifies intrinsic ATP-dependent helicase activity in HPV16 E2 protein, identifies key residues for this activity, and shows E2 inhibits E1 helicase through direct interaction.

The paper identifies the C-terminal domain of influenza A virus PA protein as the active center for endonuclease activity and a novel antiviral target, revealing potential drug resistance mutations and new inhibitors.

This study identifies a non-covalent interaction between Ebola virus VP35 and ubiquitin chains that supports viral replication and discovers compounds that block this interaction to reduce viral activity.