Jérôme Guicheux

This study develops a 3D model to recapitulate the transition from human mesendoderm progenitors to nucleus pulposus-like cells using single-cell transcriptomics and spatial profiling.

The paper identifies immune endotypes in OA synovial tissue using integrated molecular and spatial profiling to guide precision medicine.

This paper compares transcriptomic and functional differences between healthy and degenerated ovine intervertebral disc cells, finding age-related inflammatory and senescence signatures and shared transcriptional modules with human degenerated discs.

This paper develops a degradable PCLA nanofibrous scaffold for annulus fibrosus repair, showing accelerated degradation and tissue regeneration in ovine models.

This study identifies mitochondrial alterations in osteoarthritic chondrocytes and shows that bezafibrate improves OxPhos function in a subset of patients.

This paper develops a 3D in vitro model of an ovine intervertebral disc using a PCL frame and alginate hydrogel, demonstrating effective cell alignment and phenotype preservation.

The paper uses spatial profiling to identify macrophage networks in RA synovium linked to treatment response.

This study shows EZH2 inhibition reduces cartilage damage, synovial inflammation, and pain in OA by modulating inflammatory, neuroimmune, and osteoimmune pathways.

This study develops covalent alginate hydrogels using SPAAC cross-linking for encapsulating human adipose MSCs, demonstrating their viability and immunomodulatory activity in vitro.