Paul Humbert

This paper compares transcriptomic and functional differences between healthy and degenerated ovine intervertebral disc cells, finding age-related inflammatory and senescence signatures and shared transcriptional modules with human degenerated discs.

This paper develops a degradable PCLA nanofibrous scaffold for annulus fibrosus repair, showing accelerated degradation and tissue regeneration in ovine models.

The paper uses spatial profiling to identify macrophage networks in RA synovium linked to treatment response.