Aidan E. Cowan

This paper introduces a carbon cofeeding strategy to overcome stoichiometric limitations in redox-balance growth coupling, enabling growth-coupled selection for biosynthetic pathways in engineered E. coli.

This paper engineers Escherichia coli to use hydrogen and formate as energy sources, improving mevalonate production by 57.6% through metabolic decoupling.

The paper maps the sequence-to-function relationship of rubisco by assaying single amino acid mutants in E. coli, identifying conserved positions and mutations that improve CO2 affinity.